The flood of information on gene and protein sequences from the genome projects has revolutionzed molecular and evolutionary biology and led to the rapid development of the science called genomics. Reliable prediction of the function of a novel gene/protein requires complex computational analysis of genomic and protein sequence information, which exploit the principles governing the evolution of protein structure and function. This book aims to provide an up-to-date summary of the principles of protein evolution and discusses both the methods available to analyse the evolutionary history of proteins and to predict their.
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